Crown Gall at a guess, a bacterial disease (Agrobacterium tumefaciens) of Euonymus, that also infects Poplar, Hawthorns, fruit trees, etc..
See:
https://www.rhs.org.uk/advice/profile?PID=141

Agree. It's very contagious so I would check with internet sites but I imagine it's close of play to you euonymous and its fellow shrub.

What a shame, its a lovely little shrub (Its one of the silver variegated Euonymus fortunii)

You could take a few cuttings from your other one but they can be very slow to get going. I'd play safe and plant something herbaceous there instead for a few years.

Thanks everyone. Very disappointing the answer, but I bow to the knowledge of you all. Spade and fork to the ready.....thinking about planting spuds in its place as the website link suggests, the good lady is already saying she will not eat them!! Haha

Gosh, Iciar rides again!